Trienrokol aqua is a complex antimicrobial veterinary product of a wide spectrum of action, the therapeutic effect is the influence of the active ingredients of the veterinary drug: enrofloxacin, trimethoprim and colistin sulfate, which exhibit synergistic joint action, providing a wide range of antimicrobial activity against gram-positive and gram-negative microorganisms.
Enrofloxacin belongs to the 3rd generation of fluoroquinolones, is a derivative of quinol carboxylic acid, the mechanism of action is to inhibit the activity of the enzyme gyrase, which affects the replication of the DNA helix in the nucleus of a bacterial cell, which leads to damage of protein synthesis and suppression of growth and development gram-positive and gram-negative bacteria, including: gram-positive: aerobic cocci - Staphylococcus spp., Streptococcus spp.; anaerobic spore-forming bacteria - Clostridium perfringens; gram-negative: aerobic bacteria - Escherichia coli, Haemophilus spp., Salmonella spp., Bordetella spp .; as well as Campylobacter spp., Corynebacterium pyogenes, Pseudomonas aeruginosa and Mycoplasma spp.
Colistin sulfate is a peptide antibiotic of the polymyxin group, the antibacterial activity of which extends mainly to the gram-negative microflora, its mechanism of action is associated with a violation of the permeability of the cytoplasmic membrane of bacteria sensitive to it, is synthesized by the aerobic spore-forming bacillus Bacillus polymyxa and has a pronounced bactericidal effect in relation to most aerobic gram-negative microorganisms, including: gram-negative: aerobic bacteria - Escherichia coli, Salmonella spp.; Pasteurella spp., Bordetella spp.; as well as Klebsiella spp., Pseudomonas aeruginosa.
Trimethoprim is active against a wide range of microorganisms, including gram-positive and gram-negative bacteria: gram-positive: aerobic cocci - Staphylococcus spp., Streptococcus spp.; anaerobic spore-forming bacteria - Cloctridium spp.; gram-negative: aerobic bacteria - Escherichia coli, Klebsiella spp., as well as Proteus spp.; as well as chlamydia, nocardia (actinomycetes), some mycobacteria, protozoa and many anaerobic bacteria.
The action against gram-negative bacteria extends to Haemophilus parainfluenzae, Haemophilus ducreyi, Citrobacter freundii and others, Klebsiella oxytoka and others, Enterobacter cloacae, Serratiamar cescens, etc.
The mechanism of action of trimethoprim is associated with inhibition of the enzyme dihydrofolate reductase, during the formation of tetrahydrofolic acid. This leads to depletion of folate, the main cofactor of nucleic acid synthesis, as a result, the production of nucleic acids and bacterial protein is disrupted. With simultaneous use with sulfonamides, a synergistic effect is noted in relation to the suppression of the production of tetrahydrofolic acid.
Enrofloxacin is well and quickly absorbed in the gastrointestinal tract and penetrates into all organs and tissues of animals, is excreted from the body mainly unchanged, mainly in the urine and in small quantities with feces.
Colistin sulfate is practically not absorbed in the gastrointestinal tract, does not accumulate in organs and tissues, it is excreted from the body mainly unchanged with feces.
Trimethoprim is absorbed in the gastrointestinal tract quickly and almost completely, the maximum concentration is reached after 1-4 hours. Trimethoprim crosses the placenta and is excreted in milk, excreted from the body mainly unchanged.
