Stovek

Tiakol-TRV

Description:

Tiakol-TPV is an antimicrobial veterinary product.

Dosage form: oral powder.

Composition:

1 g of which contains 450 mg of tiamulin hydrogen furamate, 1,200,000 IU (equivalent to 55 mg) of colistin sulfate and filler (dextrose).

Indications for use:

The drug is used to treat pigs and poultry with staphylococcosis, streptococcosis, listeriosis, colibacillosis, salmonellosis, klebsiella, mycoplasmosis, chlamydia, borreliosis; enzootic pneumonia, dysentery and erysipelas of pigs, as well as other infectious diseases of pigs and poultry, the pathogens of which are sensitive to tiamulin and colistin.

Method of administration and dosage:

The drug is administered orally, individually or in groups, mixed with feed or drinking water, once a day, for 3-5 days in the following doses:

Pigs

200-450 g per 1 ton of feed or drinking water

Poultry

250-500 g per 1 ton of feed or drinking water.

Pharmaceutical properties

The combination of tiamulin and colistin, which are part of the drug, has a broad spectrum of antibacterial action against gram-positive (Staphylococcus spp., Streptococcus spp., Listeria monocytogenes, Corynebacterium spp., Erysipelothrix rhusiopathiae, Clostridium spp.) and gram-negative bacteria (Escherichia coli, Enterobacter spp., Bacteroides spp., Brachyspira hyodysenteriae, Brachyspira pilosicoli, Bacteroides spp., certain species of Klebsiella spp., Salmonella spp., Fusobacterium spp.), as well as against Mycoplasma spp., Chlamydia spp., Rickettsia spp., Borrelia spp.

The mechanism of action of tiamulin is to bind to the 50-S ribosomal subunit of sensitive microorganisms, which leads to disruption of protein synthesis in the bacterial cell.

Colistin is an antibiotic from the polymyxin group. The mechanism of action of colistin sulfate is to disrupt the integrity of the cytoplasmic membrane of the microbial cell.

After oral administration of the drug, tiamulin is absorbed in the gastrointestinal tract and penetrates into all organs and tissues of the body, reaching maximum concentrations in the blood serum after 2-3 hours. The therapeutic concentration is maintained for 18-24 hours after administration.

Colistin sulfate is slightly absorbed from the gastrointestinal tract and has a local antibacterial effect there.

The drug is metabolized in the liver and excreted from the body mainly with feces. In case of liver and kidney dysfunction, the excretion period may increase.

The mechanism of action consists of inhibiting the activity of the enzyme gyrase, which affects the replication of the DNA helix in the nucleus of the bacterial cell, which leads to disruption of protein synthesis and suppression of bacterial growth and development.