Stovek

Tetraflox aqua

Description:

Tetraflox aqua is an antibacterial veterinary product.
Dosage form: oral solution.

Composition:

1 ml of the drug contains 50 mg of tilmicosin, 25 mg of levofloxacin, 25 mg of trimethoprim, excipients (sodium formaldehyde sulfoxylate, EDTA disodium salt, acetic acid) and solvent (purified water).

Indications for use:

The drug is used to treat pigs and poultry in case of diseases caused by microorganisms sensitive to the active ingredients of the drug.

The drug is prescribed for diseases of the respiratory system, gastrointestinal tract, genitourinary system; in case of colibacillosis, pasteurellosis, salmonellosis, staphylococcosis, streptococcosis, necrotic enteritis, dysentery, hemophilia, ornitobacteriosis, mycogylasmosis, chlamydia and other diseases.

Method of administration and dosage:

The drug is administered orally with drinking water for 3-5 days in the following doses:

Pigs

0.25-0.5 ml per 1 kg of animal body weight. Group method - 1-2 l of the drug per 1 ton of water

Poultry

0.25-0.5 ml per 1 kg of bird body weight. Group method - 1-2 liters of the drug per ton of water

For group administration, pigs and poultry shall receive only water containing the drug. The prepared solution of the drug must be used within 24 hours. When preparing the stock solution, the drug is added to water.

Pharmaceutical properties

The active substances of the drug complement each other, thereby expanding the spectrum of antimicrobial activity.

The combination of active ingredients is highly active against gram-negative (Mycoplasma spp., Campylobacter spp., Enterobacter spp., Escherichia coli, Haemophilus spp., Klebsiella spp., Pasteurella spp., Proteus spp., Pseudomonas spp.. Salmonella spp., Rickettsia spp., Bordetella spp., Ornithobacterium rhinotracheale) and gram-positive microorganisms (Staphylococcus spp.. Streptococcus spp., Enterococcus spp., Mycobacterium spp., Clostridium spp., Lysteria monocytogenes, Corynebacterium spp.)

Tilmicosin is a semi-synthetic broad-spectrum macrolide antibiotic. The mechanism of antimicrobial effect is to block protein synthesis in the microbial cell at the ribosomal level.

Levofloxacin is a synthetic broad-spectrum antimicrobial bactericidal agent from fluoroquinolones group. The mechanism of action is associated with the blockade of DNA gyrase and topoisomerase IV, impaired supercoiling and cross-linking of deoxyribonucleic acid breaks, inhibition of deoxyribonucleic acid synthesis, and profound metabolic changes in the cytoplasm, cell wall and membranes.

Trimethoprim is an antibacterial agent from diaminopyrimidines group. The mechanism of action is to inhibit bacterial dihydrofolate reductase.

All components of the drug have high bioavailability; after oral administration, they are quickly absorbed from the gastrointestinal tract and penetrate into most organs and tissues. The maximum concentration in blood serum is reached in 1-2 hours, the therapeutic concentration is preserved for 24-48 hours. The active ingredients of the drug are excreted from the body in the form of metabolites and unchanged with urine and bile.