Stovek

Sulfapim Aqua-TRV

Description:

Sulfaprim Aqua-TRV is an antibacterial veterinary product.
Dosage form: oral solution.

Composition:

1 ml of the drug contains 200 mg of sulfadimidine, 40 mg of trimethoprim, as well as excipients (dimethylacetamide, methylpyrrolidone, polyvinylpyrrolidone, polysorbate 80, disodium salt of ethylenediaminetetraacetic acid, propylene glycol) and solvent (highly purified water).

Indications for use:

The drug is used to treat calves, lambs, horses, pigs and poultry with echirichiosis, pasteurellosis, campylobacteriosis, staphylococcosis, streptococcosis, listeriosis, eimeriosis, chlamydia, mycoplasmosis. bordetellosis, swine hemophilosis and other infections of bacterial etiology, the pathogens of which are sensitive to the components of the drug.

Method of administration and dosage:

The drug is administered orally for 3-5 days in the following doses:

Calves and lambs (up to 3 months of age), horses

Individually 1-2 ml per 16 kg of animal body weight twice a day with a small amount of drinking water, milk, skim milk, whole milk substitute

Pigs

Individually 1-2 ml of the drug per 16 kg of animal body weight with a small amount of feed or water. Group method - 0.5-1 l of the drug per ton of drinking water

Poultry

Up to 4 weeks of age - 0.0625-0.125 ml per 1 kg of bird weight or 0.25-0.5 liters per ton of drinking water, older than 4 weeks - 0.0625 ml per 1 kg of bird weight or 0.5-1 liter per ton of drinking water. In case of bird eimeriosis, the dose of the drug is 2 liters per ton of drinking water.

With salmonellosis, mixed infections, as well as with chronic forms of poultry diseases, the course of treatment is extended to seven days. During the treatment period, animals and birds should receive only water containing the drug. The prepared solution of the drug must be used within 24 hours.

Pharmaceutical properties

Active substances exhibit synergy, the drug acts bactericidal against gram-negative (Escherichia coli, Klebsiella spp., Proteus spp., Campylobacter spp., Pseudomonas aeruginosa, Bordetella spp., Pasteurella spp., Haemophilus spp., Actinobacillus spp.) and gram-positive bacteria (Staphylococcus spp., Streptococcus spp., Listeria monocytogenes, Corynebacterium spp.), Eimeria, Chlamydia, Mycoplasmas.

Sulfadimidine, as part of the drug, is an antibacterial agent from sulfonamides group. The mechanism of action is due to competitive antagonism with para-aminobenzoic acid, inhibition of dihydropteroate synthetase, impaired synthesis of tetrahydrofolic acid, which is necessary for the synthesis of purines and pyrimidines.

Diaminopyrimidine derivative, trimethoprim, has a slow bactericidal effect; it reversibly inhibits bacterial dihydrofolate reductase, disrupts the synthesis of tetrahydrofolic acid from dihydrofolic acid, the formation of purine and pyrimidine bases, nucleic acids, thereby inhibiting the growth and reproduction of microorganisms. The combination of trimethoprim with sulfadiazine is characterized by a bactericidal effect and a wide spectrum of activity, including microflora resistant to many antimicrobial drugs.

After oral administration of the drug, sulfadimidine and trimethoprim are absorbed in the gastrointestinal tract and penetrate into all organs and body tissues, reaching maximum concentrations in blood serum after 2-3 hours. Therapeutic concentration is maintained for 24 hours after administration.

The drug is excreted from the body with urine and feces, in lactating animals - partly with milk, in birds - with eggs. In case of impaired liver and kidney function, an increase in the elimination period is possible.