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Catalog Veterinary products Antibiotic

Parofid 20%-TRV

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Parofid 20%-TRV

Description:

Parofid 20%-TPV is an antimicrobial veterinary product.

Dosage form: oral powder.

Composition:

1 gram contains 200 mg paromycin sulfate, excipients (silicon dioxide) and excipient (dextrose).

Indications for use:

The drug is used to treat pigs, calves and poultry with infectious diseases of the gastrointestinal tract of bacterial etiology caused by microorganisms sensitive to paromomycin, including escherichiosis, salmonellosis, as well as histomoniasis of birds, cryptosporidiosis of calves and piglets.

Method of administration and dosage:

The drug is administered orally for 3-5 days in the following doses:

Pigs

individually 1.25-2.0 g per 10 kg of animal body weight once a day;

group method - 2.2-5.0 kg of the drug per 1000 kg of feed or 1.0-2.5 kg of the drug per 1000 liters of drinking water.

Poultry

broiler chickens, parent flock, replacement young animals) – 37.5-70 mg of the drug per kg of live weight of the bird; group method - 0.5-1.5 kg of the drug per 1000 kg of feed or 0.25-0.75 kg of the drug per 1000 liters of drinking water.

Calves

for calves up to 3 months of age - individually 1.25-2.5 g per 10 kg of animal body weight once a day with a small amount of feed, water, milk or whole milk substitute.

Pharmaceutical properties

Paromomycin sulfate, which is part of the drug, belongs to a broad-spectrum antibiotic from the aminoglycoside group, which also has an antiprotozoal effect.

Shows activity against gram-positive (Staphylococcus spp., Streptococcus spp., Listeria monocytogenes, Corynebacterium spp.), and gram-negative bacteria (Escherichia coli, Enterobacter spp., Klebsiella spp., Salmonella spp.), as well as some protozoa (Histomonas meleagridis, Cryptosporidium spp.).The mechanism of action of the drug is its binding to specific receptor proteins on the 30-S subunit of ribosomes and subsequent disruption of the formation of the transport and messenger RNA complex.As a result of such interactions, protein synthesis stops (bacteriostatic effect). In high concentrations, paromomycin causes destruction of the cytoplasmic membrane of the microbial cell with its rapid subsequent death (bactericidal effect).

Paromomycin sulfate is poorly absorbed from the gastrointestinal tract, providing high concentrations in it, exerting an effect in the intestinal lumen, on the mucous membrane and in the submucosal layer. Paromomycin sulfate does not undergo biotransformation and is quickly excreted from the body, mainly unchanged with feces and partly by the kidneys.f liver and kidney function are impaired, the elimination period may be increased.

In terms of the degree of danger of impact on the body, the drug is classified as a low-hazard substance (hazard class 4 according to GOST 12.1.007-76).