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Catalog Veterinary products Antibiotic

Florol 10% aqua-TRV

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Florol 10% aqua-TRV

Description:

Florol 10% aqua-TRV is an antibacterial veterinary product.

Dosage form: oral solution.

Composition:

1 ml contains 100 mg of florfenicol as an active substance and excipients - polyethylene glycol, propylene glycol, 1-methyl 2-pyrrolidone.

Indications for use:

Florol 10% aqua-TRV is used as a therapeutic agent in pigs and poultry for treatment colibacillosis, salmonellosis, pasteurellosis, staphylococcosis and other infectious diseases of poultry caused by microorganisms susceptible to florfenicol, as well as for pleuropneumonia, atrophic rhinitis and porcine infections.

Method of administration and dosage:

The veterinary product is administered orally in drinking water.

Pigs

5 ml of the veterinary product per 100 kg or 0.05 ml per 1 kg of animal weight (according to API - 5 mg per 1 kg of animal weight) for 7 days.

Chickens up to 4 weeks

1 l of the veterinary product per 1000 l of water (according to API - 20 mg per 1 kg of animal weight) for 3 days.

Poultry - other age categories

2 l of the veterinary product per 1000 l of water (according to API - 20 mg per 1 kg of animal weight) within 3 days, in case of salmonellosis treatment is performed for 5 days.

Pharmaceutical properties

Florol 10% aqua-TRV belongs to the broad-spectrum antibacterial veterinary products of the fenicol group. Florfenicol is an antibiotic derived from thiamphenicol that has a bacteriostatic effect against gram-positive and gram-negative bacteria, including: gram-negative aerobic bacteria - Pasteurella spp., Bordetella bronchiseptica, Escherichia coli, Salmonella spp., Klebsiella spp., Haemophilus spp.; gram-positive aerobic cocci - Streptococcus spp., Staphylococcus spp., as well as Fusobacterum necrophorum, and Mycoplasma spp.

The mechanism of action of florfenicol is based on the suppression of bacterial protein synthesis by binding to the 70S ribosome subunit. Veterinary product resistance develops relatively slowly, and cross-resistance to other chemotherapeutic agents does not occur.

When administered orally, florfenicol is well absorbed from the gastrointestinal tract and penetrates into most organs and tissues, but does not cross the blood-tissue barriers. The bioavailability of florfenicol is 88% in pigs, 55% in poultry, the maximum concentration in blood serum is reached 1-1.5 hours after the veterinary product is applied and lasts for 24 hours. It is excreted from the body mainly in urine, and less in faeces.

Florol 10% aqua-TRV, according to the degree of exposure to the body, is classified as a low-hazard substance (hazard class 4 according to GOST 12.1.007-76).