Enrotrim aqua is a combined broad-spectrum antibacterial veterinary product, the antibacterial effect is due to the synergism of the action of trimethoprim and enrofloxacin against gram-positive and gram-negative microorganisms.
Enrofloxacin belongs to the group of fluoroquinolones. It has a wide spectrum of antibacterial and including antimycoplasma action, inhibits the growth and development of gram-positive and gram-negative bacteria, incl. Escherichia coli, Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Clostridium spp., Leptospira spp., Actinobacterium spp., Bordetella spp., Compylobacter spp., Somonium spp. , Rickettsia spp., Proteus spp., Mycoplasma spp.
The mechanism of action of enrofloxacin on a bacterial cell is based on blocking protein synthesis by inhibiting bacterial DNA gyrase, which leads to disruption of DNA synthesis in microbial cell.
Enrofloxacin is well and rapidly absorbed from the gastrointestinal tract and is distributed in organs and tissues. Therapeutic concentrations are achieved after 1 -1.5 hours after administration and persist for 24 hours.
Trimethoprim is a broad-spectrum antimicrobial agent from the group of diaminopyrimidines. Trimethoprim has an antimicrobial effect on gram-positive and gram-negative microorganisms: Escherichia coli, Salmonella spp., Pasteurella spp., Enterobacter spp., Proteus spp., Staphylococcus spp., Streptococcus spp., Haemophilus spp., Chlamstidium spp. spp., Actinobacterium spp., Bordetella spp., Compylobacter spp., Corynebacterium spp., Pseudomonas spp., Rickettsia spp., Mycoplasma spp., and also acts on Toxoplasma and Eimeria.
The mechanism of action is associated with the inhibition of bacterial dihydrofolic acid reductase.
It is metabolized in the liver and excreted mainly in urine. Concentration in urine is much higher than in blood. The half-life is 8-10 hours.
