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Catalog Veterinary products Antibiotic

Enrofloxacin 20-TRV

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Enrofloxacin 20-TRV

Description:

Enrofloxacin 20-TPV is an antimicrobial veterinary product.

Dosage form: oral powder.

Composition:

1 gram contains 200 mg of enrofloxacin and excipients (dextrose).

Indications for use:

Enrofloxacin 20-TPV is used as a therapeutic agent in pigs and poultry for respiratory and gastrointestinal diseases of bacterial etiology, including colibacillosis, salmonellosis, pasteurellosis, necrotic enteritis, atrophic rhinitis, hemophilosis, mycoplasmosis, staphylococcosis, streptococcosis, as well as coinfections and secondary infections, the causative agents of which are sensitive to enrofloxacin.

Method of administration and dosage:

The veterinary product is administered orally with drinking water or feed once a day for 3-5 days.

Poultry

with feed - 0.5 kg of the veterinary product per ton of feed;

with water - 0.5 kg of the veterinary product per ton of water.

Pigs

with feed - 0.0125 - 0.025 g of the veterinary product (2.5-5 mg of API) per 1 kg of body weight.

For treatment of salmonellosis and in severe cases of swine disease, the dose of the veterinary product is doubled.

Pharmaceutical properties

Enrofloxacin, active substance of the veterinary product, belongs to the group of 3rd generation fluoroquinolones and has a wide spectrum of antibacterial action, is active against gram-positive and gram-negative bacteria, including Escherichia coli, Haemophilus spp., Salmonella spp., Klebsiella spp. , Pasteurella multocida, Pseudomonas spp., Bordetella spp., Campylobacter spp., Corynebacterium spp., Staphylococcus spp., Streptococcus spp., Actinobacillus spp., Clostridium spp., Bacteroides spp., Fusobacterium necrophorum and Mycoplasma spp. Bacterial resistance to enrofloxacin develops relatively slowly.

The mechanism of the antimicrobial action of enrofloxacin is to inhibit the activity of the enzyme gyrase, which affects the replication of the DNA helix in the nucleus of the bacterial cell.

Enrofloxacin is well and quickly absorbed from the gastrointestinal tract and penetrates into all organs and tissues of the body. The maximum concentration of the veterinary product in the blood is reached 1-2 hours after the administration of the veterinary product and lasts for 6 hours, and the therapeutic concentration - for 24 hours. It is excreted from the body mainly unchanged in urine and in small quantities in faeces, in poultry - in droppings.

Enrofloxacin 20-TPV, according to the exposure degree, refers to substances of low hazard (hazard class 4 according to GOST 12.1.007-76).