Doxycycline is a semisynthetic tetracycline derivative (oxytetracycline derivative). Active against gram-positive and gram-negative microorganisms, incl. Actinobacillus pleuropneumoniae, Clostridium spp., Escherichia coli (some strains), Staphylococcus spp., Streptococcus spp., Haemophilus spp., Pasteurella spp., As well as Mycoplasma spp., Rickettsia spp., Chlamydia spp.

The mechanism of the bacteriostatic action of the antibiotic -it exerts its action by inhibiting the protein synthesis by reversible binding to the 30S ribosomal subunit of microorganisms sensitive to the veterinary product.

Doxycycline is well absorbed into the bloodstream from the gastrointestinal tract and widely distributed in the organisms. The maximum concentration of the antibiotic in the blood serum is reached after 2-4 hours and is maintained at a therapeutic level for at least 18-24 hours after using the veterinary product.

Doxycycline is excreted primarily in faeces.

Tylosin is an antibiotic from the macrolide group. It is active against most gram-positive and gram-negative microorganisms, including Staphylococcus spp., Streptococcus spp., Corynebacterium spp., Erysipelothrix rhusiopathiae, Clostridium spp., Escherichia coli (some strains), Klebsiella spp., Proteus spp., Salmonella spp., Campus spp.., Bordetella spp., Pasteurella spp., Haemophilus spp., and also Mycoplasma spp., Chlamydia spp.

The mechanism of action of tylosin is based on inhibition of protein synthesis in a microbial cell by blocking the enzyme translocase.

When administered orally, the veterinary product is rapidly absorbed from the gastrointestinal tract and enters all organs and tissues. The highest concentrations of tylosin are found in the lungs, liver, mammary gland and kidneys. The therapeutic concentration of the antibiotic in the blood is maintained for 15-18 hours.

The veterinary product is excreted from the body mainly in faeces.