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Catalog Veterinary products Antibiotic

Colistin aqua

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Colistin aqua

Description:

Colistin aqua is an antibacterial preparation.

Dosage form: oral solution.

Composition:

1 ml contains active ingredient colistin sulfate – 4 000 000 IU, excipients - propylene glycol, citric acid, lactic acid, highly purified water.

Indications for use:

The veterinary product is used to treat pigs, calves and poultry with colibacillosis, salmonella, pasteurellosis and other bacterial diseases of the gastrointestinal tract, the causative agents of which are sensitive to colistin.

Method of administration and dosage:

The veterinary product is administered orally with drinking water individually or in groups for 3-5 days.

Poultry

individually - 0.2 ml of the veterinary product per 10 kg of body weight or 0.02 ml per 1 kg of body weight;

in groups - 100-125 ml of the veterinary product per 1000 L of drinking water.

Pigs

individually - 0.25-0.5 ml of the veterinary product per 10 kg of body weight per day (diluted with drinking water in a ratio of 1:10);

in groups - 0.25-0.5 L of the veterinary product per 1 ton of water.

Calves

individually - 0.1-0.25 ml of the veterinary product per 10 kg of animal body weight or 0.01-0.025 ml of the veterinary product per 1 kg of animal body weight (diluted with drinking water in a ratio of 1:10).

Pharmaceutical properties

Colistin is a peptide antibiotic of the polymyxin group, the antibacterial activity of which extends mainly to gram-negative microflora. It is synthesized by the aerobic spore-forming bacillus Bacillus polymyxa and has a pronounced bactericidal effect against most aerobic gram-negative microorganisms, including Escherichia coli, Salmonella spp., Pasteurella spp., Bordetella spp., Klebsiella spp., Pseudomonas aeruginosa.

The mechanism of bactericidal action of colistin is to disrupt the permeability of the cytoplasmic membrane, which leads to its destruction and subsequent lysis of the bacterial cell. Bacterial resistance to colistin develops very slowly.

With oral administration of the veterinary product, colistin sulfate is practically not absorbed in the gastrointestinal tract, is not affected by digestive enzymes and does not accumulate in tissues, which creates conditions for obtaining a high antibacterial concentration of colistin in the intestinal lumen and allows you to obtain excellent results in the treatment of intestinal diseases caused by gram-negative bacteria.

Colistin is excreted mainly in feces, mainly in an unchanged form.