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Catalog Veterinary products Antibiotic

Coli 12-TRV

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Coli 12-TRV

Description:

Coli 12-TPV is an antimicrobial veterinary product.

Dosage form: oral powder.

Composition:

1 gram of the product contains 12,000,000 IU of colistin sulfate and excipients (ascorbic acid, citric acid, sucrose).

Indications for use:

Coli 12-TPV is used to treat pigs, calves, sheep and poultry with colibacteriosis, salmonellosis and other infectious diseases of the gastrointestinal tract of bacterial etiology, the pathogens of which are sensitive to colistin.

Method of administration and dosage:

The veterinary product is administered orally to animals and poultry in a group or individual way in a mixture with feed or drinking water, for 3-5 days, in doses: 5-8 mg per 1 kg of body weight, with feed.

Pigs

5-8 mg per 1 kg of body weight with feed

5-8 mg per 1 kg of body weight, with water

Poultry

50-75 gram of the veterinary product per 1000 liters of water

Pharmaceutical properties

Colistin (as sulfate) is an antibiotic of the polymyxin group, which are synthesized by the aerobic spore-forming bacillus Bacillus polymyxa. It is active against a number of gram-negative microorganisms, including: Escherichia coli, Pseudomonas aeruginosa, Haemophilus spp., Klebsiella spp., Proteus spp., Salmonella spp., Pasteurella spp.

The mechanism of bactericidal action of colistin sulfate lies in its combination with bacterial lipoproteins and violation of the cell wall permeability, which leads to the loss of amino acids, inorganic ions, purine and pyrimidine bases by the bacterial cell and causes its death.

When administered orally, the veterinary product is practically not absorbed from the gastrointestinal tract and has an antimicrobial effect directly in the intestine.

Colistin sulfate is excreted from the body unchanged, mainly with feces and urine.

Coli 12-TRV, according to the degree of the exposure, belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007-76).