Azithromycin 10% -TRV is a broad-spectrum antibacterial veterinary product.

Azithromycin is an antibiotic of the macrolide group, the azalide subgroup has a bactericidal effect on gram-positive and gram-negative microorganisms, including: gram-negative - Actinobacillus pleuropneumoniae, Actinobacillus lignieresi, Mannheimia haemolytica, Pasteurella multocida, Haemophilppppella Campocella. , Fusobacterium necrophorum, Salmonella spp., Escherichia coli; gram-positive - Listeria spp., Staphylococcus spp., Streptococcus spp., Clostridium perfringens; and also Chlamydia spp., Mycoplasma bovis and Mycoplasma hyopneumoniae.

The mechanism of action of azithromycin is associated with inhibition of protein biosynthesis by the ribosomes of bacteria (the formation of peptide bonds between amino acids and the peptide chain is disrupted).

Azithromycin has a postantibiotic effect - persistent inhibition of the vital activity of bacteria after their short-term contact with an antibacterial veterinary product. The effect is based on irreversible changes in the ribosomes of the microorganism, resulting in a persistent translocation block. Due to this, the general antibacterial effect of the veterinary product is enhanced and prolonged, remaining for the period necessary for the resynthesis of new functional proteins of the microbial cell.

The veterinary product is well absorbed and quickly distributed in the tissues of the body, reaching high concentrations, many times higher than the concentration in blood plasma. The maximum concentration of the antibiotic in the blood is reached after 30-60 minutes, and the therapeutic concentration remains in the body of animals for up to 72 hours, in the lungs and macrophages for up to 120 hours.

Azithromycin 10% -TRV is eliminated mainly unchanged with the urine and bile.

Azithromycin 10% -TRV, according to the degree of exposure, belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007-76).