Amoxicillin is a penicillin group semi-synthetic antibiotic. It has a wide spectrum of bactericidal action against gram-positive bacteria (Actinomyces spp., Bacillus anthracis, Clostridium spp., Corynebacterium spp., Erysipelothrix rhusiopathiae, Listeria monocytogenes, Staphylococcus spp., Streptococcus spp., Streptococcus spp. coli, Salmonella spp., Fusobacterium necrophorum, Haemophilus spp., Moraxella spp., Pasteurella spp., Proteus mirabilis). The veterinary product has no effect on penicillinase-forming strains of microorganisms from the genera Klebsiella and Enterobacter, as well as Pseudomonas.
Amoxicillin inhibits the synthesis of the bacterial cell wall, inhibiting the enzymes transpeptidase and carboxypeptidase and causes an imbalance in the osmotic balance, which leads to the death of bacteria during the growth stage.
Amoxicillin is well absorbed into the bloodstream from the gastrointestinal tract and is rapidly distributed in the organs and tissues. The maximum concentration in blood plasma is reached within 1-2 hours after administration.
Clavulanic acid (potassium clavulanate) is a beta-lactamase inhibitor. It contains a beta-lactam structure similar to that of beta-lactam antibiotics. It has its own antibacterial activity. Like other beta-lactams, clavulanic acid is able to bind to penicillin-binding proteins (PBPs) of gram-positive and gram-negative bacteria and promote lysis of a bacterial wall.
